Miklossy J, Neuroreport 1993 Jul;4(7):841-8 as of 23 September 1998 NeuroReport 4, §41-§48 (1993) NeuroReport Vol. 4 No. 7 July 1993 [pages 841-848]
Alzheimer's Disease--A Spirochetosis?
Judith Miklossy University Institute of Pathology, Division of Neuropathology, University of Lausanne, Rue du Bugnon 27, 1005 Lausanne, Switzerland
The aetiology of Alzheimer's disease (AD), which affects a large proportion of the aged population is unknown and the treatment unresolved. The role of beta amyloid protein (ßA4), derived from a larger amyloid precursor protein (APP) in AD is the subject of intense research. Here I report observations that in 14 autopsy cases, with histopathologically confirmed AD, spirochetes were found in blood and cerebrospinal fluid and, moreover, could be isolated from brain tissue. Thirteen age-matched control cases were without spirochetes. Reference strains of spirochetes and those isolated from brains of AD patients, showed positive immunoreaction with monoclonal antibody against the ß amyloid precursor protein. These observations suggest that spirochetes may be one of the causes of AD and that they may be the source of the ß amyloid deposited in the AD brain. .....See full text http://www.geocities.com/HotSprings/Retreat/1593/ad-miklossy-study.txt